OXGR1

OXGR1 (also known as Oxoglutarate receptor 1) is a protein that in humans is encoded by the OXGR1 gene. It is a member of the G protein-coupled receptor family, a large family of cell surface receptors that respond to a variety of external signals.

Function

OXGR1 is a receptor for alpha-ketoglutarate (α-KG), an important intermediate in the Krebs cycle. The binding of α-KG to OXGR1 activates the receptor, leading to the production of cAMP, a second messenger that regulates many cellular processes.

Clinical significance

Alterations in the function of OXGR1 have been implicated in a number of diseases, including cancer, diabetes, and neurodegenerative diseases. For example, in cancer, high levels of α-KG can promote tumor growth by activating OXGR1. In diabetes, OXGR1 may play a role in insulin secretion.

Research

Research into the function of OXGR1 and its role in disease is ongoing. This research may lead to the development of new treatments for diseases in which OXGR1 plays a role.

See also

• G protein-coupled receptor
• Krebs cycle
• cAMP