OXGR1
OXGR1 (also known as Oxoglutarate receptor 1) is a protein that in humans is encoded by the OXGR1 gene. It is a member of the G protein-coupled receptor family, a large family of cell surface receptors that respond to a variety of external signals.
Function[edit | edit source]
OXGR1 is a receptor for alpha-ketoglutarate (α-KG), an important intermediate in the Krebs cycle. The binding of α-KG to OXGR1 activates the receptor, leading to the production of cAMP, a second messenger that regulates many cellular processes.
Clinical significance[edit | edit source]
Alterations in the function of OXGR1 have been implicated in a number of diseases, including cancer, diabetes, and neurodegenerative diseases. For example, in cancer, high levels of α-KG can promote tumor growth by activating OXGR1. In diabetes, OXGR1 may play a role in insulin secretion.
Research[edit | edit source]
Research into the function of OXGR1 and its role in disease is ongoing. This research may lead to the development of new treatments for diseases in which OXGR1 plays a role.
See also[edit | edit source]
References[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
