TAAR6

TAAR6 (Trace Amine Associated Receptor 6) is a protein that in humans is encoded by the TAAR6 gene. TAAR6 belongs to a family of G protein-coupled receptors that are predominantly expressed in the brain and are known to play key roles in many biological functions and diseases.

Function

TAAR6 is a member of the TAAR family of receptors, which are unique among G protein-coupled receptors in their ability to bind and be activated by trace amines. Trace amines are a group of endogenous compounds that play crucial roles in cellular regulation, particularly in the brain. They are thought to have a significant effect on mood and behavior, and alterations in their levels have been linked to a variety of mental and neurological disorders, including depression, schizophrenia, and Parkinson's disease.

Structure

The TAAR6 protein is a seven-transmembrane domain receptor that is coupled to a G protein. It is primarily expressed in the brain, particularly in the amygdala and hippocampus, regions that are involved in emotion and memory, respectively.

Clinical significance

Alterations in the TAAR6 gene have been associated with a variety of psychiatric disorders. For example, a study found that certain polymorphisms in the TAAR6 gene were associated with an increased risk of schizophrenia. Another study found that variations in the TAAR6 gene were associated with bipolar disorder.

See also

• Trace amine-associated receptor
• G protein-coupled receptor
• Schizophrenia
• Bipolar disorder

References

edit 

WikiMD neurology

External links

• Comprehensive information from the National Institute of health.
  

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