Prostaglandin DP1 receptor

Prostaglandin D2 receptor 1 (also known as DP1) is a protein that in humans is encoded by the PTGDR gene. DP1 belongs to the G protein-coupled receptor family, and it is one of two known receptors for the prostaglandin D2 (PGD2).

Function

DP1 is a receptor for prostaglandin D2. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the downstream physiological effects. The activation of DP1 by PGD2 or by synthetic analogs induces an increase in intracellular cAMP in numerous tissues including brain, retina, and airway smooth muscle cells.

Clinical significance

DP1 has been implicated in a variety of physiological and pathological processes. It plays a significant role in the regulation of allergic responses. Activation of DP1 by PGD2 or by synthetic analogs can inhibit the chemotaxis of eosinophils, basophils, and Th2 lymphocytes, and can prevent the production of Th2 cytokines from human Th2 cells in response to antigen or IL-2.

In addition, DP1 is involved in the regulation of sleep. PGD2 is a potent sleep-inducing substance and its production is increased during sleep. The activation of DP1 by PGD2 induces sleep in rats.

See also

• Prostaglandin receptors
• Prostaglandin D2

External links

• "Prostanoid Receptors: DP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.