D1-type
Dopamine receptor D1 (also known as DRD1) is one of the five subtypes of dopamine receptors in the human body. It is a G protein-coupled receptor that stimulates adenylyl cyclase and is involved in various neurological processes.
Function[edit | edit source]
The D1-type dopamine receptor is the most abundant dopamine receptor in the central nervous system. This receptor is involved in neuropsychological processes such as motor control, cognition, and reward. It is also involved in the regulation of mood and in the pathophysiology of schizophrenia.
Structure[edit | edit source]
The D1-type dopamine receptor is a transmembrane protein that is encoded by the DRD1 gene. It is a member of the G protein-coupled receptor family and is coupled to the G protein Gs, which activates adenylyl cyclase.
Clinical significance[edit | edit source]
Alterations in the function or expression of the D1-type dopamine receptor have been implicated in several neuropsychiatric disorders, including schizophrenia, drug addiction, and Parkinson's disease. Antagonists of the D1 receptor have been used in the treatment of these disorders.
See also[edit | edit source]
- Dopamine receptor
- D2-type dopamine receptor
- D3-type dopamine receptor
- D4-type dopamine receptor
- D5-type dopamine receptor
References[edit | edit source]
D1-type Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD