D1-type
Dopamine receptor D1 (also known as DRD1) is one of the five subtypes of dopamine receptors in the human body. It is a G protein-coupled receptor that stimulates adenylyl cyclase and is involved in various neurological processes.
Function[edit | edit source]
The D1-type dopamine receptor is the most abundant dopamine receptor in the central nervous system. This receptor is involved in neuropsychological processes such as motor control, cognition, and reward. It is also involved in the regulation of mood and in the pathophysiology of schizophrenia.
Structure[edit | edit source]
The D1-type dopamine receptor is a transmembrane protein that is encoded by the DRD1 gene. It is a member of the G protein-coupled receptor family and is coupled to the G protein Gs, which activates adenylyl cyclase.
Clinical significance[edit | edit source]
Alterations in the function or expression of the D1-type dopamine receptor have been implicated in several neuropsychiatric disorders, including schizophrenia, drug addiction, and Parkinson's disease. Antagonists of the D1 receptor have been used in the treatment of these disorders.
See also[edit | edit source]
- Dopamine receptor
- D2-type dopamine receptor
- D3-type dopamine receptor
- D4-type dopamine receptor
- D5-type dopamine receptor
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
