D1-type

Dopamine receptor D1 (also known as DRD1) is one of the five subtypes of dopamine receptors in the human body. It is a G protein-coupled receptor that stimulates adenylyl cyclase and is involved in various neurological processes.

Function

The D1-type dopamine receptor is the most abundant dopamine receptor in the central nervous system. This receptor is involved in neuropsychological processes such as motor control, cognition, and reward. It is also involved in the regulation of mood and in the pathophysiology of schizophrenia.

Structure

The D1-type dopamine receptor is a transmembrane protein that is encoded by the DRD1 gene. It is a member of the G protein-coupled receptor family and is coupled to the G protein Gs, which activates adenylyl cyclase.

Clinical significance

Alterations in the function or expression of the D1-type dopamine receptor have been implicated in several neuropsychiatric disorders, including schizophrenia, drug addiction, and Parkinson's disease. Antagonists of the D1 receptor have been used in the treatment of these disorders.

See also

• Dopamine receptor
• D2-type dopamine receptor
• D3-type dopamine receptor
• D4-type dopamine receptor
• D5-type dopamine receptor

D1-type Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski