Mirtazepine

What Is Mirtazapine

Mirtazapine tablets are indicated for the treatment of major depressive disorder (MDD) in adults.

What are the uses of this medicine?

• Mirtazapine is an atypical antidepressant and is used primarily for the treatment of a major depressive disorder.

The drug has sedative, antiemetic, anxiolytic, and appetite stimulant effects, which explains its off-label use for the following conditions:

• insomnia
• panic disorder
• post-traumatic stress disorder
• obsessive-compulsive disorder
• generalized anxiety disorder
• social anxiety disorder
• headaches
• migraines

Most commonly, clinicians prescribe mirtazapine when individuals have not achieved success with initial pharmacological therapies for major depressive disorder, and they use it predominantly in depressed individuals with insomnia and/or individuals who are underweight.

Who Should Not Use  ?

• Do not give mirtazapine to any patient who is currently on MAO inhibitors.
• There should be a gap of at least 14 days between the discontinuation of an MAO inhibitor (intended to treat psychiatric disorders) and therapy initiation with mirtazapine.
• Do not give mirtazapine to any patient currently receiving intravenous methylene blue or linezolid because of an increased risk of serotonin syndrome.

Is this medicine FDA approved

• Mirtazapine came into medical use in the United States in 1996.
• The patent expired in 2004, and generic versions are available.
• In 2018, it was the 99th most commonly prescribed medication in the United States, with more than 7 million prescriptions.

How should this medicine be used?

• The currently recommended starting dose for mirtazapine 15-mg once daily; may increase up to maximum recommended dose of 45 mg once daily.
• Administer orally once daily, preferably in the evening prior to sleep.
• Reduce dose gradually when discontinuing mirtazapine tablets.

What are the dosage forms and brand names of this medicine?

This medicine is available in following dosage forms:

• 7.5 mg, 15 mg scored, 30 mg scored, and 45 mg.

This medicine is available in following brand names:

• Remeron®
• Remeron® SolTab

What side effects can this medication cause?

Common possible side effects of fluoxetine include:

increased weight and appetite

• dry mouth
• dizziness
• anxiousness
• confusion
• drowsiness
• constipation
• nausea
• vomiting

Adverse reactions may include:

• Drowsiness
• Weight gain
• Xerostomia
• Increased serum cholesterol
• Constipation
• Increased appetite

What special precautions should I follow?

• Mirtazapine tablets should be discontinued if sore throat, fever, stomatitis or signs of infection occur, along with a low white blood cell count is observed.
• Mirtazapine may impair judgment, thinking and/or motor skills. Use with caution when engaging in activities requiring alertness, such as driving or operating machinery.
• Use with caution in patients with a seizure disorder.
• Use with caution in patients with impaired hepatic function.

What to do in case of emergency/overdose?

• Signs and symptoms reported in association with overdose included disorientation, drowsiness, impaired memory, and tachycardia.
• No specific antidotes for mirtazapine are known.

Can this medicine be used in pregnency?

• There are no reliably identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.
• There are risks associated with untreated depression in pregnancy.

What should I know about storage and disposal of this medication?

• Store at 20° to 25°C (68° to 77°F); excursions permitted 15° to 30°C (59° to 86°F).
• Protect from light and moisture.

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• Dailymed label info on Mirtazepine
• FDA Mirtazepine

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