Quinidine gluconate

Quinidine Gluconate is a pharmaceutical drug used primarily to treat cardiac arrhythmias. It is a stereoisomer of quinine, which is an anti-malarial drug. Quinidine gluconate is classified as a Class Ia antiarrhythmic agent, and it works by blocking the fast inward sodium current, which extends the phase 0 depolarization, which in turn prolongs the action potential.

Pharmacology

Quinidine gluconate is a quinidine salt that is used for its antiarrhythmic properties. It works by blocking the fast inward sodium current, which extends the phase 0 depolarization, which in turn prolongs the action potential. This results in a decrease in the heart's automaticity and a delay in the recovery time between heartbeats. Quinidine gluconate also has anticholinergic and alpha-blocking effects.

Clinical Use

Quinidine gluconate is used to treat a variety of cardiac arrhythmias, including atrial fibrillation, atrial flutter, and ventricular arrhythmias. It is also used in the treatment of malaria, as it is a stereoisomer of quinine, an anti-malarial drug.

Side Effects

Like all medications, quinidine gluconate can cause side effects. These can include nausea, diarrhea, and dizziness. More serious side effects can include cardiotoxicity, cinchonism, and thrombocytopenia.

Contraindications

Quinidine gluconate is contraindicated in patients with certain conditions, including myasthenia gravis, hypersensitivity to quinidine or quinine, and certain types of heart block.

See Also

• Quinidine
• Cardiac arrhythmia
• Atrial fibrillation
• Malaria