CDX1
CDX1 is a homeobox gene that encodes a transcription factor involved in the regulation of cellular differentiation in the intestinal epithelium. It is a member of the caudal-related homeobox transcription factor family, and plays a crucial role in embryogenesis and organogenesis.
Function[edit | edit source]
The CDX1 gene is expressed in the intestinal epithelial cells, where it regulates the expression of other genes involved in the differentiation and maintenance of these cells. It is also involved in the regulation of gastrointestinal development during embryogenesis.
Clinical Significance[edit | edit source]
Mutations in the CDX1 gene have been associated with various types of cancer, including colorectal cancer and gastric cancer. These mutations can lead to abnormal expression of the CDX1 protein, which can disrupt normal cellular differentiation and lead to the development of cancer.
Research[edit | edit source]
Research into the CDX1 gene and its associated protein has provided valuable insights into the mechanisms of cellular differentiation and cancer development. Further research is needed to fully understand the role of CDX1 in these processes and to develop potential therapeutic strategies for cancers associated with CDX1 mutations.
See Also[edit | edit source]
- Homeobox
- Transcription factor
- Cellular differentiation
- Intestinal epithelium
- Embryogenesis
- Organogenesis
- Colorectal cancer
- Gastric cancer
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Contributors: Prab R. Tumpati, MD
