Prolactin-inhibiting hormone

Prolactin-Inhibiting Hormone (PIH), also known as Dopamine, is a neurohormone produced in the hypothalamus that plays a crucial role in the regulation of prolactin secretion from the anterior pituitary gland.

Function

PIH inhibits the secretion of prolactin from the anterior pituitary gland. This inhibition is achieved by PIH binding to dopamine receptors on the lactotroph cells in the anterior pituitary, which reduces the release of prolactin.

Structure

PIH is a simple peptide hormone, composed of 22 amino acids. It is synthesized in the hypothalamus and transported to the anterior pituitary gland via the hypophyseal portal system.

Clinical Significance

Abnormal levels of PIH can lead to disorders such as hyperprolactinemia, characterized by an excess of prolactin in the blood, and hypoprolactinemia, characterized by a deficiency of prolactin. These conditions can result in symptoms such as galactorrhea, amenorrhea, and infertility.

See Also

• Prolactin
• Hypothalamus
• Anterior pituitary gland
• Dopamine
• Hyperprolactinemia
• Hypoprolactinemia