8-M-PDOT
8-M-PDOT (8-methyl-6-(2-(pyrrolidin-1-yl)ethyl)-6H-indolo[4,3-fg]quinoline) is a chemical compound that acts as a potent and selective agonist of the 5-HT2A receptor, a subtype of the serotonin receptor. It is structurally related to other psychedelic compounds such as LSD and psilocybin.
Chemical Structure and Properties[edit | edit source]
8-M-PDOT is a member of the tryptamine class of compounds, which are characterized by their indole ring structure. The chemical formula for 8-M-PDOT is C20H22N2, and it has a molecular weight of 290.40 g/mol. The compound features a methyl group at the 8-position of the indole ring, which is thought to contribute to its unique pharmacological properties.
Pharmacology[edit | edit source]
8-M-PDOT is known for its high affinity and selectivity for the 5-HT2A receptor, which is a G protein-coupled receptor (GPCR) involved in various neurological processes, including mood regulation, perception, and cognition. Activation of the 5-HT2A receptor by agonists like 8-M-PDOT can lead to psychedelic effects, which are characterized by altered states of consciousness, visual and auditory hallucinations, and changes in thought processes.
Mechanism of Action[edit | edit source]
The mechanism of action of 8-M-PDOT involves binding to the 5-HT2A receptor and activating it, which leads to a cascade of intracellular signaling events. This activation can result in the release of neurotransmitters such as dopamine and glutamate, which are involved in the modulation of mood and perception.
Research and Applications[edit | edit source]
Research on 8-M-PDOT has primarily focused on its potential as a tool for studying the 5-HT2A receptor and its role in psychiatric disorders such as schizophrenia, depression, and anxiety. Due to its selectivity, 8-M-PDOT is used in laboratory settings to differentiate the effects of 5-HT2A receptor activation from those of other serotonin receptor subtypes.
Safety and Legal Status[edit | edit source]
As of the latest updates, 8-M-PDOT is not approved for medical use and is primarily used in research settings. Its legal status may vary by country, and it is important for researchers to comply with local regulations regarding the handling and use of psychoactive substances.
Also see[edit | edit source]
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