CXCR2
CXCR2 is a G protein-coupled receptor that in humans is encoded by the CXCR2 gene. It is a part of the interleukin-8 receptor family and is also known as the IL8RB gene. CXCR2 is primarily expressed in neutrophils, one of the primary types of white blood cells in the immune system.
Function[edit | edit source]
CXCR2 is a receptor for Interleukin-8 which is a powerful neutrophil activator. It is involved in neutrophil migration to sites of inflammation. The receptor is available in several cellular subsets in addition to neutrophils. It is also expressed in T-cells, monocytes, and several other cell types.
Clinical significance[edit | edit source]
Alterations in CXCR2 function can lead to various medical conditions. For instance, it has been implicated in the pathophysiology of several diseases such as chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis. In addition, CXCR2 has been identified as a potential therapeutic target for cancer treatment, as it is involved in tumor growth, angiogenesis, and metastasis.
Research[edit | edit source]
Research into the role of CXCR2 in disease progression and the development of CXCR2 antagonists as potential therapeutic agents is ongoing. Several pharmaceutical companies are currently developing drugs that target CXCR2, with the hope of treating various inflammatory and malignant diseases.
See also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
