CXCR2

CXCR2 is a G protein-coupled receptor that in humans is encoded by the CXCR2 gene. It is a part of the interleukin-8 receptor family and is also known as the IL8RB gene. CXCR2 is primarily expressed in neutrophils, one of the primary types of white blood cells in the immune system.

Function

CXCR2 is a receptor for Interleukin-8 which is a powerful neutrophil activator. It is involved in neutrophil migration to sites of inflammation. The receptor is available in several cellular subsets in addition to neutrophils. It is also expressed in T-cells, monocytes, and several other cell types.

Clinical significance

Alterations in CXCR2 function can lead to various medical conditions. For instance, it has been implicated in the pathophysiology of several diseases such as chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis. In addition, CXCR2 has been identified as a potential therapeutic target for cancer treatment, as it is involved in tumor growth, angiogenesis, and metastasis.

Research

Research into the role of CXCR2 in disease progression and the development of CXCR2 antagonists as potential therapeutic agents is ongoing. Several pharmaceutical companies are currently developing drugs that target CXCR2, with the hope of treating various inflammatory and malignant diseases.

See also

• Chemokine receptor
• Interleukin-8
• Neutrophil
• G protein-coupled receptor

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