4-HO-NMT

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4-HO-NMT, also known as 4-hydroxy-N-methyltryptamine or psilocin-N-methyl analog, is a psychedelic compound of the tryptamine class. It is structurally related to psilocin, the active compound in psilocybin mushrooms.

Chemical Structure and Properties

4-HO-NMT is a tryptamine derivative, characterized by a core indole structure with a hydroxyl group at the 4-position and a methylamino group at the ethyl side chain. Its chemical formula is C₁₁H₁₄N₂O, and it has a molecular weight of 190.24 g/mol.

Pharmacology

The pharmacological properties of 4-HO-NMT are not well-studied, but it is believed to act as a partial agonist at the 5-HT_2A receptor, similar to other psychedelic tryptamines. This receptor is thought to play a key role in the psychedelic effects of compounds like psilocin and LSD.

Effects

The effects of 4-HO-NMT are largely anecdotal, as it has not been widely studied in humans. Users report effects similar to those of psilocin, including altered perception, visual hallucinations, and changes in thought patterns. The duration of effects is typically shorter than that of psilocin, lasting around 4 to 6 hours.

Legal Status

4-HO-NMT is not specifically scheduled under the Controlled Substances Act in the United States, but it may be considered an analog of psilocin, which is a Schedule I substance. This could potentially subject it to prosecution under the Federal Analog Act.

History and Research

4-HO-NMT was first synthesized by the chemist Alexander Shulgin and is mentioned in his book TiHKAL (Tryptamines I Have Known and Loved). However, it has not been the subject of extensive scientific research or clinical trials.

Also see

• Psilocin
• Psilocybin
• Tryptamine
• Serotonin receptor
• Psychedelic drug