25E-NBF

25E-NBF is a synthetic compound that belongs to the class of phenethylamines, specifically a derivative of the 2C family of psychedelic substances. It is structurally related to the more well-known compound 25I-NBOMe, which is a potent agonist of the 5-HT_2A receptor and is known for its psychedelic effects.

Chemical Structure and Properties

25E-NBF is chemically known as 2-(4-ethoxy-2,5-dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine. It features a phenethylamine core with a 2,5-dimethoxy substitution pattern on the phenyl ring, an ethoxy group at the 4-position, and a fluorobenzyl group attached to the nitrogen atom.

Molecular Formula: C₁₉H₂₄FNO₃

Molecular Weight: 333.40 g/mol

Pharmacology

25E-NBF is believed to act as a potent agonist at the 5-HT_2A receptor, similar to other compounds in the NBOMe series. This receptor is a subtype of the serotonin receptor and is primarily responsible for the psychedelic effects of these substances. The binding affinity and efficacy of 25E-NBF at this receptor, however, have not been extensively studied.

Effects

The effects of 25E-NBF are largely anecdotal and based on user reports, as there is limited scientific research on this compound. Users have reported experiencing:

• Visual and auditory hallucinations
• Altered perception of time and space
• Euphoria and mood enhancement
• Increased introspection and philosophical thinking

Due to its potency, 25E-NBF can produce these effects at very low doses, which increases the risk of overdose and adverse reactions.

Risks and Safety

The safety profile of 25E-NBF is not well-established. However, compounds in the NBOMe series are known to have a high potential for toxicity, especially at higher doses. Reported adverse effects include:

• Severe vasoconstriction
• Hypertension
• Tachycardia
• Seizures
• Agitation and confusion

Due to these risks, the use of 25E-NBF is discouraged outside of a controlled research setting.

Legal Status

The legal status of 25E-NBF varies by country. In many jurisdictions, it is considered a controlled substance due to its structural similarity to other banned NBOMe compounds. Users should be aware of the legal implications of possessing or distributing this substance.

Also see

• 25I-NBOMe
• 2C family
• Psychedelic phenethylamines
• 5-HT2A receptor