Trifluoroescaline

A synthetic psychedelic compound

Trifluoroescaline (also known as TFE) is a synthetic psychedelic compound belonging to the phenethylamine class. It is structurally related to mescaline, a naturally occurring psychedelic found in the peyote cactus, but with three fluorine atoms replacing hydrogen atoms on the aromatic ring.

Chemical Structure and Properties

Trifluoroescaline is a derivative of escaline, which itself is a derivative of mescaline. The chemical structure of trifluoroescaline is characterized by the presence of three fluorine atoms at the 2, 4, and 5 positions of the aromatic ring, and a methoxy group at the 3 position. This trifluorination significantly alters the compound's pharmacological properties compared to its non-fluorinated analogs.

Chemical Formula: C₁₀H₁₀F₃NO

Molecular Weight: 217.19 g/mol

Pharmacology

The pharmacological effects of trifluoroescaline are not well-documented, as it is a relatively obscure compound with limited research. However, it is believed to act as a serotonin receptor agonist, similar to other psychedelic phenethylamines. The trifluorination may enhance its binding affinity to certain serotonin receptor subtypes, potentially altering its potency and duration of action.

Effects

Due to the lack of comprehensive studies, the effects of trifluoroescaline are largely anecdotal. Users have reported experiencing:

• Visual and auditory hallucinations
• Altered perception of time and space
• Euphoria and emotional changes
• Increased introspection and philosophical thinking

The onset of effects typically occurs within 30 to 60 minutes after oral ingestion, with a duration of action lasting 6 to 10 hours.

Safety and Toxicity

The safety profile of trifluoroescaline is not well-established. As with many research chemicals, there is a potential for unknown risks and adverse effects. Users should exercise caution and adhere to harm reduction practices when experimenting with such substances.

Legal Status

Trifluoroescaline is not specifically scheduled under international drug control treaties. However, its legal status may vary by country, and it could be considered an analog of controlled substances under certain jurisdictions.

History and Research

Trifluoroescaline was first synthesized in the late 20th century as part of research into fluorinated phenethylamines. Its synthesis and characterization were documented in chemical literature, but it has not been widely studied in humans or animals.

Also see

• Phenethylamine
• Mescaline
• Psychedelic drug
• Serotonin receptor