Isobuscaline

A synthetic psychedelic compound related to mescaline

Isobuscaline is a synthetic psychedelic compound that belongs to the phenethylamine class of drugs. It is structurally related to mescaline, a naturally occurring psychedelic found in certain cacti, such as the Peyote cactus. Isobuscaline is known for its psychoactive effects, which are similar to those of mescaline, but it is not as well-studied or widely used.

Chemical Structure and Properties

Isobuscaline is chemically known as 2-(3,5-dimethoxy-4-isopropoxyphenyl)ethanamine. It is a phenethylamine derivative, characterized by the presence of a phenyl ring with methoxy and isopropoxy substituents, and an ethylamine chain. The molecular formula of isobuscaline is C₁₃H₂₁NO₃, and it has a molecular weight of 239.31 g/mol.

Pharmacology

The pharmacological effects of isobuscaline are not well-documented, but it is believed to act as a partial agonist at the 5-HT2A receptor, similar to other psychedelic phenethylamines. This receptor is known to play a key role in the modulation of mood, perception, and cognition, which are affected during psychedelic experiences.

Effects

The effects of isobuscaline are reported to be similar to those of mescaline, including altered states of consciousness, visual and auditory hallucinations, and changes in perception of time and space. Users may also experience emotional and cognitive shifts, such as enhanced introspection and altered thought patterns.

History and Synthesis

Isobuscaline was first synthesized by chemists exploring the structure-activity relationships of mescaline analogs. The synthesis involves the alkylation of 3,5-dimethoxy-4-hydroxyphenethylamine with isopropyl bromide, followed by purification steps to isolate the final product.

Legal Status

The legal status of isobuscaline varies by country. In many jurisdictions, it is not specifically listed as a controlled substance, but it may be considered illegal under analog drug laws that prohibit compounds structurally similar to controlled substances like mescaline.

Research and Potential Uses

Research on isobuscaline is limited, and its potential therapeutic uses have not been extensively explored. However, like other psychedelics, it may have potential applications in psychotherapy, particularly in the treatment of conditions such as depression, anxiety, and post-traumatic stress disorder (PTSD).

Safety and Toxicity

The safety profile and toxicity of isobuscaline are not well-established. As with other psychedelics, there may be risks associated with its use, including psychological distress, "bad trips," and potential interactions with other substances or medications.

Also see

• Mescaline
• Phenethylamine
• Psychedelic therapy
• Serotonin receptor