Loxapine hydrochloride

Loxapine Hydrochloride is an antipsychotic medication used primarily in the treatment of schizophrenia. It belongs to the class of dibenzoxazepine derivatives and is marketed under various brand names such as Loxitane and Adasuve.

Pharmacology

Loxapine Hydrochloride acts by blocking the dopamine receptors in the brain, specifically D2 receptors. This action helps to reduce the symptoms of schizophrenia. It also has some effect on the serotonin receptors, which may contribute to its therapeutic effects.

Uses

Loxapine Hydrochloride is primarily used in the treatment of schizophrenia. It may also be used off-label for other conditions as determined by a healthcare provider.

Side Effects

Common side effects of Loxapine Hydrochloride include drowsiness, dizziness, and dry mouth. More serious side effects can include tardive dyskinesia, a condition characterized by involuntary movements, and neuroleptic malignant syndrome, a potentially life-threatening reaction to antipsychotic drugs.

Precautions

Patients with a history of seizures, heart disease, or liver disease should use Loxapine Hydrochloride with caution. It should not be used in patients with a known hypersensitivity to the drug.

Interactions

Loxapine Hydrochloride can interact with a number of other medications, including other antipsychotics, antidepressants, and certain heart medications. It is important to inform healthcare providers of all medications being taken to avoid potential interactions.

See Also

• Antipsychotic
• Schizophrenia
• Dopamine
• Serotonin
• Tardive dyskinesia
• Neuroleptic malignant syndrome