Imipramine hydrochloride

Imipramine Hydrochloride is a type of tricyclic antidepressant (TCA) that is primarily used in the treatment of depression and enuresis. It is sold under the brand names Tofranil and Tofranil-PM among others.

History

Imipramine was first synthesized in the 1950s and was the first TCA to be developed. It was originally intended to be an antipsychotic, but was found to have antidepressant properties. The hydrochloride salt form, imipramine hydrochloride, was later developed to improve the drug's solubility and absorption.

Pharmacology

Imipramine hydrochloride works by inhibiting the reuptake of certain neurotransmitters, specifically norepinephrine and serotonin, in the brain. This increases the levels of these neurotransmitters in the brain, which can help to alleviate symptoms of depression.

Uses

Imipramine hydrochloride is primarily used to treat depression. It can also be used to treat enuresis in children, although it is not a first-line treatment for this condition. Other off-label uses include the treatment of panic disorder, chronic pain, and attention deficit hyperactivity disorder (ADHD).

Side Effects

Common side effects of imipramine hydrochloride include dry mouth, blurred vision, constipation, and dizziness. More serious side effects can include cardiac arrhythmias, seizures, and suicidal ideation.

See Also

• Tricyclic antidepressant
• Depression
• Enuresis