Imipramine pamoate
Imipramine hydrochloride is a type of tricyclic antidepressant (TCA) that is used primarily in the treatment of depression. It is also used in the treatment of enuresis (involuntary urination), and panic disorder. Imipramine hydrochloride was the first TCA to be developed and has been in use since the 1950s.
History[edit | edit source]
Imipramine hydrochloride was first synthesized in the late 1940s by the Swiss pharmaceutical company Geigy (now part of Novartis). It was initially developed as a potential treatment for schizophrenia, but was found to be ineffective for this purpose. However, during clinical trials, it was observed that the drug had a significant effect on mood, leading to its development as an antidepressant.
Pharmacology[edit | edit source]
Imipramine hydrochloride works by inhibiting the reuptake of certain neurotransmitters, specifically norepinephrine and serotonin, in the brain. This increases the levels of these neurotransmitters in the synaptic cleft, which in turn leads to an elevation of mood.
Side effects[edit | edit source]
Like all TCAs, imipramine hydrochloride can have a number of side effects. These can include dry mouth, blurred vision, constipation, weight gain, and dizziness. More serious side effects can include cardiac arrhythmias, seizures, and an increased risk of suicide.
See also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
