CCR7

CCR7 is a gene in humans that encodes the C-C chemokine receptor type 7 protein. This protein is a member of the G protein-coupled receptor family. The encoded protein is a receptor for the C-C type chemokines CCL19/MIP-3 beta and CCL21/6Ckine and is a key regulator of the migration and organization of immune cells.

Function

The protein encoded by the CCR7 gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.

Clinical significance

CCR7 has been shown to be involved in various diseases such as cancer and autoimmune diseases. In cancer, CCR7 expression is associated with lymph node metastasis. In autoimmune diseases, CCR7 guides T cells and dendritic cells to lymphoid organs where they contribute to the disease development.

See also

• Chemokine receptor
• Cluster of Differentiation

External links

• CCR7 at GeneCards

CCR7 Resources
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